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By D.F. Swaab, E. Fliers, M. Mirmiran, W.A. Van Gool and F. Van Haaren (Eds.)

ISBN-10: 0444807934

ISBN-13: 9780444807939

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6200 M D Maastricht. The Netherlands Introduction There has been extensive research into psychological dysfunctions in aging and senile dementia over the past 30 years. A number of papers have appeared on deficits in intellectual, memory, language, and several other cognitive functions. The research knowledge has been acquired generally in group comparison studies and - unfortunately - only very recently attempts have been made to use this knowledge for the assessment of individual patients. In addition, attempts to relate the psychological dysfunctions to the underlying cerebral substrate have been relatively scarce.

The restlessness already noted in stage 1 increases; patients become upset at night, and they tend to wander around. They may constantly be manipulating things in their hands. Emotionally, patients in this stage often retain sufficient insight into their condition to develop secondary anxiety and depression; the dementia may thus appear more severe than it is. Stage 3. With further progression, the patients develop a clear aphasia, apraxia and agnosia. Spontaneous speech decreases further; there is a tendency to echo what is said (echolalia); there is greatly reduced comprehension and an inability to name objects.

In addition to speed, memory, verbal and perceptual factors, a factor called ‘general ability’ is an important determinant for the performance on intelligence tests. 50 (Botwinnick, 1981). Taken together, studies with intelligence tests have not provided unequivocal results with respect to the nature of the deficits in aging. The same applies for dementia. Demenfiu. As the term ‘dementia’ implies a disturbance in cognitive functioning, many studies have addressed themselves to the determination of intellectual deficits in dementing subjects.

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Aging of the Brain and Alzheimer's Disease by D.F. Swaab, E. Fliers, M. Mirmiran, W.A. Van Gool and F. Van Haaren (Eds.)

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