By K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)
The illnesses that fall lower than the generalized team of demyelinating illnesses -Multiple Sclerosis, Leukodystrophyes, Encephalomyelitis-are the point of interest of globally situation. This quantity comprises papers provided by way of best scientists who attended the NATO complicated study Workshop held on the Istituto Superiore di SanitA, Rome, March 1-4, 1993. This e-book is an replace of the former one released in 1987 of the study mentioned at an analogous assembly held in 1986. It was once made up our minds to carry this second assembly when you consider that there was nice growth within the advances in realizing the myelinogenesis procedure within the final 5 years. The workshop collected jointly scientists from many fields resembling mobile and molecular biology, immunology, pathology, virology and naturally medical neurology. Stimulating rules have been exchanged within the wish that extra wisdom of demyelinating illnesses can result in new theraupetic ways. even supposing the workshop used to be most likely just like the former one, this time there has been extra emphasis on experimental types and medical points. within the former using animal and mobile versions as instruments for figuring out the pathological mechanisms associated with human disorder have been mentioned; within the latter the clinicians defined the filtering down of easy study to scientific remedy The e-book of this interdisciplinary alternate is to make recognized the result of the latest study one of the investigators from allover the area eager about those studies.
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Additional info for A Multidisciplinary Approach to Myelin Diseases II
20. C. Myelin acquisition in the central nervous system of the mouse revealed by an MBP-IacZ transgene. J. Neurosci. 12: 4890-4897 (1992). 21. A. Myelin basic protein gene contains separate enhancers for oligodendrocyte and Schwann ccll expression. J. Cell BioI. 119:605-616 (1992). 22. , and Sanes, I. Integration site-dependent expression of a transgene reveals specialized features of cells associated with neuromuscular junctions. J. Cell. BioI. 113:1385-1397 (1991). 23. , and Zalc B. Clonal segregation of oligodendrocytes and astrocytes during in vitro differentiation of progenitor cells.
Expression and deposition of four major myelin constituents in the myelin sheath during development: an in vivo study. Dev. Neurosci. 8:222-235 (1986). 3. 4. 5. 6. 7. W. Proteins of myelin. In: Myelin, P. ) Plenum Press, New York, pp. 197-224 (1984). , and Hood, L. 5-kD MBPs by alternate use of exons. Cell 42:139-148 (1985). A. Alternative splicing accounts for the four fonns of myelin basic protein. Cell 43: 721-727 (1985). , and Mikoshiba, K. Identification of new isoforms of mouse myelin basic protein: the existence of exon 5a.
The amplification products were separated by gel electrophoresis and visualized by autoradiography. Quantification of the radiolabeled products was performed by densitometric scanning (Personal Densitometer, Molecular Dynamics). Relative PMP22 mRNA levels were calculated by normalizing optical densities for the control cell extinction. behaviour starting with an initial phase of proliferation and reaching a saturation density around day 6. It is very interesting to note that the proliferation of Schwann cells overexpressing PMP22 is significantly reduced compared to control cells or cells underexpressing PMP22 mRNA.
A Multidisciplinary Approach to Myelin Diseases II by K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)